You can exclude individual items or whole collections of items from coupon use.
Exclude one item
To do that, you can mark any single item with the block coupon option
Exclude many items
Use the in-line editor and the ‘Block Coupon’ column to assign a bunch of items at once to either blocked or unblocked for coupon use. For example, here we can assign 200 LEGO items at a time for blocked coupons.